Objective: To study the profile of patients with PSA level between 2.6 and 10.0 ng/ml and submitted to prostate biopsy, determining possible patterns that might lead to a reduction of unnecessary biopsies. Materials and Methods: In the period from 2007 to 2009, a cross-sectional study was developed with 1,282 patients with PSA levels between 2.6 and 10.0 ng/ml, and submitted to prostate biopsy. Results: Cancer prevalence was 28.6%. On average, the patients with positive biopsies were older, with higher PSA levels and density, and smaller prostate volume as compared with the patients with negative biopsies. In the analysis of PSA density, the cancer patients averaged 0.31 ng/ml/cc, while patients with negative results averaged 0.10 ng/ml/cc. Utilizing a cutoff value of 0.15 ng/ml/cc for PSA density as a cancer positiveness criterion, the authors obtained sensitivity of 74% and specificity of 70%. The cutoff value should be reduced to increase the sensitivity. With a cutoff value of 0.09 ng/ml/cc, sensitivity reached 84% (CI 95%: 80–87%), and specificity, 75% (CI 95%: 72–78%). Conclusion: The systematic use of PSA density as an indicator to proceed with the investigation of a patient with biopsy could substantially reduce the amount of unnecessary procedures.

Keywords: Prostate; Prostate biopsy; Prostate cancer; PSA density.

Objective: To determine the sensitivity of upper gastrointestinal (UGI) series, adopting the 24-h esophageal pH monitoring as the gold standard in the diagnosis of gastroesophageal reflux disease (GERD) in preterm newborns, besides describing the presence of anatomical abnormalities in the digestive tube. Materials and Methods: The present study included 41 neonates with average birth weight of 1,243.9 g, presenting signs/symptoms of GERD and abnormal 24-h esophageal pH monitoring (reflux index > 10%). The UGI series was performed as soon as the infants’ clinical conditions were considered sufficiently stable. Results: The 24-h pH monitoring and UGI series were performed respectively at 49.8 and 66.8 days of life. The UGI series sensitivity was of 39.0 (CI 95%: 25.7–54.3%). The reflux index was significant in 41.4%, moderate in 44.8%, and mild in 13.8% of the cases. Only one case of hiatus hernia was identified by UGI series. Conclusion: Upper gastrointestinal series has demonstrated low sensitivity in the diagnosis of GERD in preterm newborns and was not associated with the reflux severity as compared with pH monitoring. However, it is useful in the detection of anatomical abnormalities in the upper gastrointestinal tract.

Keywords: Gastroesophageal reflux disease; Upper gastrointestinal series; 24-h esophageal pH monitoring; Preterm newborns.

Objective: To describe high-resolution computed tomography findings in several diseases that run their course with the “crazy-paving” pattern. Materials and Methods: The present study has evaluated seven patients with diagnoses of alveolar proteinosis, bronchioloalveolar carcinoma, lipoid pneumonia and pneumocystosis, correlating tomographic and pathological findings. Results: In the cases of pneumocystosis, the alveolar spaces were filled with foamy material where parasitic organisms intermingled with surfactants, fibrin and cell debris were observed. In the cases of bronchioloalveolar carcinoma, the septa were thickened by associated fibrosis or lymphangitis, with the alveolar walls internally lined with tumor cells, and production of mucus. In the patient with alveolar proteinosis, the septa were thickened by edema, with alveolar filling determined by lipoprotein. In the patient with mineral oil aspiration, the histopathological findings included alveolar septa thickening caused by cell proliferation, with presence of fat vacuoles in alveolar septa. Conclusion: The crazy-paving pattern offers a wide range of differential diagnoses and must be evaluated in conjunction with clinical findings.

Keywords: Computed tomography; Crazy-paving pattern; Pathology; Lung diseases.

Objective: To analyze radiological findings observed at high-resolution computed tomography in patients with sarcoidosis, and establishing their correlation with pathological findings. Materials and Methods: High-resolution computed tomography findings in ten patients with sarcoidosis were reviewed and correlated with findings in specimens obtained by surgical biopsy or at necropsy of four of such patients. Results: The most frequently observed finding was presence of nodules with perilymphatic distribution, predominating along bronchovascular sheaths and pleural surface, with subpleural nodules and nodular scissurae. Other less frequent findings were ground-glass attenuation and interlobular septa thickening. Conclusion: In general, all the mentioned findings demonstrated anatomopathological correlation with development of granulomas in these regions.

Keywords: Computed tomography; Sarcoidosis; Pathology; Lung diseases.

Objective: The present study was aimed at characterizing main lung changes observed in pulmonary Langerhans cell histiocytosis by means of high-resolution computed tomography. Materials and Methods: High-resolution computed tomography findings in eight patients with proven disease diagnosed by open lung biopsy, immunohistochemistry studies and/or extrapulmonary manifestations were retrospectively evaluated. Results: Small rounded, thin-walled cystic lesions were observed in the lung of all the patients. Nodules with predominantly peripheral distribution over the lung parenchyma were observed in 75% of the patients. The lesions were diffusely distributed, predominantly in the upper and middle lung fields in all of the cases, but involvement of costophrenic angles was observed in 25% of the patients. Conclusion: Comparative analysis of high-resolution computed tomography and chest radiography findings demonstrated that thin-walled cysts and small nodules cannot be satisfactorily evaluated by conventional radiography. Because of its capacity to detect and characterize lung cysts and nodules, high-resolution computed tomography increases the probability of diagnosing pulmonary Langerhans cell histiocytosis.

Keywords: Computed tomography; Langerhans cell histiocytosis; Cystic lung diseases.

Objective: To propose a reproducible, user friendly and low cost method for digitization of radiographic films of all the standard sizes, focusing efforts on chest X-ray films. Materials and Methods: The focus on low cost have dictated the use of an A4 scanner with transparency adapter, as well as an optimized image stitching software that takes advantage of the scanner geometry and constant capture area, besides the knowledge of the standard X-ray film sizes. Results: The end result of the proposed method is a high resolution image with good contrast and no perceptible stitching artifacts. Conclusion: The proposed digitization method with an A4 scanner allows reproducibility, excellent image quality and high degree of certainty in the identification of lesions.

Keywords: Digital radiology; Teleradiology; Image stitching.

Objective: To analyze the Brazilian technological innovation in the field of radiology and imaging diagnosis, in terms of patent indicators. Materials and Methods: Exploratory analytical study of information retrieved through cross queries in databases of intellectual property offices in Brazil (State Industrial Property Office [Instituto Nacional da Propriedade Industrial – INPI]), United States (United States Patent and Trademark Office – USPTO) and Europe (European Patent Office – EPO). Results: There were 277,057 patents in the field of radiology and imaging diagnosis. Of this total, 7,800 were registered at INPI (3%), 65,428 (24%) registered at the EPO and 203,829 (73%) issued by USPTO. Brazil is a signatory to 1,732 patents published by the INPI, 80 by the EPO and 26 by the USPTO. Overall, 219,993 (79%) patents were related to electronic devices strongly linked to information technology in health care, ultrasonography, tomography, magnetic resonance imaging procedures as well as to images generation, communication and archiving, and 57,064 patents (21%) dealt with technologies related to radiation protection and dosimetry, nuclear physics, electrotherapy, magnetic therapy and radiotherapy. Conclusion: The results indicate the weakness of the domestic production of patented technological innovation in the field of radiology and imaging diagnosis.

Keywords: Medical education; Science and technology; Technological innovation; Intellectual property; Research.

Objective: To evaluate the light and radiation fields congruence and radiation beam alignment in medical X-ray equipment in Paraíba state radiology centers by means of two quality control tests. Materials and Methods: A loaded cassette, a measuring tape and a bubble level were utilized in the field size and alignment testing. The evaluation of collimation systems accuracy and X-ray beam alignment was undertaken during health inspections performed in radiology centers between 2008 and 2009. Results: In 2008, 121 X-ray machines were evaluated in the Paraíba state. In 2009, 117 machines were tested. From this universe, 86 machines were selected for comparison, since they were evaluated both in 2008 and 2009, with 18.60% (n = 16) showing test results improvement from one year to another. Conclusion: The percentage of problematic X-ray machines decreased between 2008 and 2009, notwithstanding no quality assurance program has been observed in Paraíba state radiology centers.

Keywords: Equipment; X-rays; Quality control.

Following a brief description of the types of femoroacetabular impingement, the present article describes the protocol of conventional radiology, computed tomography e magnetic resonance imaging for cases of impingement, developed over the last eight years in a partnership with reference orthopedic institutions. Basic radiological propedeutics is described for each of the methods, reviewing the most relevant findings in the assessment of the hip.

Keywords: Femoroacetabular impingement; Conventional radiology; Computed tomography; Magnetic resonance imaging; Radiological propedeutics.

Multislice computed tomography is currently the imaging modality of choice for evaluating paranasal sinuses and adjacent structures. Such a method has been increasingly utilized in the assessment of anatomical variations, allowing their accurate identification with high anatomical details. Some anatomical variations may predispose to sinusal diseases, constituting areas of high risk for injuries and complications during surgical procedures. Therefore, the recognition of such variations is critical in the preoperative evaluation for endoscopic surgery.

Keywords: Multislice computed tomography; Paranasal sinuses; Anatomical variations.

Verrucous carcinoma is a variant of squamous cell carcinoma seen in mucous membranes and skin, and rarely found in the hand. The present report describes a case of two lesions on the dorsum of the hand, with no contact to each other, which underwent en-block resection and were confirmed as verrucous carcinoma.

Keywords: Verrucous; Carcinoma; Spiculated; Sea-urchin; Squamous; Hand.

Spinal lipomas are rare, accounting for 1% of all spinal tumors and being associated with occult spinal dysraphism in more than 99% of cases. Such lesions are divided into three main types, namely, lipomyelomeningoceles, intradural lipomas, and filum terminale fibrolipomas. The present report describes a case of congenital lumbosacral lipoma associated with cutaneous stigmata of the lumbar dermal sinus type.

Keywords: Occult spinal dysraphism; Congenital dermal sinus; Intradural lipoma; Ultrasonography.

Meckel’s diverticulum is the most common congenital anomaly of the gastrointestinal tract and bleeding is its most frequent complication. Scintigraphy, B-mode and Doppler ultrasonography, and computed tomography may be utilized to detect complications. The present report describes two cases of complicated Meckel’s diverticulum detected at ultrasonography whose findings were different from those described in the literature.

Keywords: Meckel’s diverticulum; Color Doppler; Ultrasonography.